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ISSN (Online): 2454-1680

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INTERNATIONAL JOURNAL OF INTEGRATED ONCOLOGY

An Official Publication Of Society Of Pharmaceutical Science & Research
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6.

PRIMARY NON-HODGKIN LYMPHOMA OF LIVER: AN UNUSUAL PRESENTATION AND REVIEW OF ITS MANAGEMENT.

 Primary Non-Hodgkin lymphoma (NHL) of liver is a very rare malignancy. Here, we report a case of 26 years old man who presented with right upper abdomen pain and lump, reduced appetite and progressive weakness of 4 month’s duration. Liver functions were deranged but serology was negative for viral markers and α Fetoprotein was within normal range. Ultrasonography and Computed Tomography scan of the abdomen revealed large nodule in right lobe of the liver. USG guided biopsy of liver mass and fluorescence in situ hybridization for CD markers established diagnosis of primary NHL of liver. Extensive investigations including X-ray of chest, whole-body positron-emission tomography scan and bone marrow biopsy showed no involve­ment of mediastinum, spleen, bone marrow or any other organ or lymph nodes significantly. Having B symptoms disease was staged IVB, the patient has been treated with 6 cycles of R-CHOP regimen (Rituximab/Cyclophosphamide–Doxorubicin–Vincristine–Prednisolone) followed by 2 courses of CHOP every three weekly. Response has been excellent and patient is asymptomatic as of now. This case highlights that primary hepatic lymphoma should be considered in the differential diagnosis of space-occupying liver lesions in presence of normal levels of...

Mukesh Kumar Bharti, Sudhakar Singh

Dr. Mukesh Kumar Bharti Assistant Professor, Dept of Radiotherapy & Oncology DMCH Laheriasarai, Darbhanga, Bihar

DOI:

35-39

2833

1214

0

2.

INCIDENTALLY DETECTED TRANSITIONAL CELL CARCINOMA IN A NONFUNCTIONING KIDNEY: SHOULD WE RELY ON RADIOLOGY?

Abstract: Primary transitional cell carcinoma (TCC) of the renal pelvis is a relatively rare disease and incidentally detected in a non-functioning kidney is much rarer. Herein, we report a case of incidentally detected histopathologically proven case of primary TCC of renal pelvis in a nonfunctioning kidney associated with staghorn calculus.

Ashwin Anand Kallianpur, Harbans Bansal, Charandeep Sahni Singh

Dr. Ashwin Anand Kallianpur, Senior Consultant, Department of Surgical Oncology, Indus Superspeciality Hospital, Mohali (INDIA)

DOI:

10-13

2678

841

0

2.

BIOMARKERS IN BREAST CANCER

Biomarkers are the molecules or tissue based processes that indicate future behavior of the cancer. Broadly classified as tissue-based and blood-based biomarkers, these need special assays over and above the routine clinical, radiological and histopathological examination. Potential of tumor biomarker ranges from risk determination through screening, differential diagnosis, prognosis and prediction to monitoring the disease. Breast cancer is the leading cause of cancer related deaths among women. With progressively better understanding of tumor biology, clinical implications of the molecular behavior are being explored for better therapeutic gains in such patients. Though, to date we have limited range of clinically useful biomarkers in breast cancer; their potential may guide us for cancer therapy in future....

Preeti Chauhan, Lalit kumar, Palki Sahib Kaur, Arockia M Babu, Ramesh Sabharwal, Yashpal Verma

Preeti Chauhan, Assistant professor, Department of Biotechnology, Chandigarh College of Technology, Mohali (INDIA)

DOI:

9-15

2671

768

0

9.

UNVEILING THE MYSTERIOUS WORLD OF SALIVARY DUCT CARCINOMA OF THE PAROTID GLAND- A RARE CASE REPORT AND REVIEW OF THE LITERATURE.

Among many variants of salivary gland tumors, salivary duct carcinoma (SDC) of the parotid gland is a highly aggressive and rare malignant tumor which ranks among those with the worst prognosis and a significant mortality. These tumors got their name based on its microscopic resemblance and being analogous to similar schemes in the ductal carcinoma of the breast. The characteristic microscopic features of salivary duct carcinoma are composed of comedo necrosis, a cribriform and papillary pattern of intraductal growth and aggressive infiltration to adjacent structures. Majority of cases are typically treated with radical parotidectomy with or without neck dissection followed by adjuvant radiotherapy. We present a case of a 60 year old male patient who presented with progressive facial paralysis and right parotid swelling. FNAC was positive for malignancy. PET-CT showed a lesion in right superficial lobe of parotid with bilateral neck nodes. Patient underwent right total parotidectomy with right radical neck dissection and left modified neck dissection. Facial nerve was preserved. Microscopic examination reported it as a salivary duct carcinoma, positive for Her2/neu antibody with lymph node metastasis (22/23). Patient received adjuvant radiotherapy and 12 cycles of Transtuzumab. There were no recurrences or metastases within 12 months of...

Irfan Bashir, Sunny Jain, Anil Thakwani, Anshul Bhatnagar, Kundan S. Chufal.

Dr. Irfan Bashir. Batra Cancer Centre, Batra Hospital and Medical Research Centre, 1 Tughlaqabad Institutional Area, M. B. Road, New Delhi, India.

DOI:

56-61

2517

1565

0

2.

Radiation induced Dysphagia in head and neck cancers-assessment and management

Disease and treatment-related swallowing dysfunction are quite common in head and neck malignancies. Though the use of high-end technology like Intensity modulated radiotherapy (IMRT) has led to a reduction in morbidity still, the issue of tolerability comes whenever a higher dose of radiation is used for tumor control. The goal of this review is to emphasize the need for documentation of pretreatment swallowing functions and look into the prospects to improve swallowing function, thence quality of life after radiotherapy by studying factors leading to this impairment. We also looked into the benefit of physiotherapy exercises to increase the capacity of...

Shailley A Sehgal, Yashpal Verma, Ashok K Chauhan

Dr Shailley Senior Resident, Department of Radiation Oncology, Pt. B. D. Sharma PGIMS, Rohtak(India)-124001

DOI:

07-14

2382

683

0

1.

QUALITY OF LIFE AFTER IMMEDIATE BREAST RECONSTRUCTION IN CARCINOMA BREAST- AN INDIAN SCENARIO.

Background: Immediate breast reconstruction (IBR) in breast cancer is a well-accepted option but is not commonly offered in India. The purpose of this study is to evaluate the quality of life after IBR. Materials and methods: This prospective study has been conducted over 40 patients of operable carcinoma breast, who underwent either modified radical mastectomy (MRM) in control group or MRM followed by IBR using autologous tissue in the study group. Both the groups were evaluated in terms of technical issues, morbidity, clinical outcome and quality of life (QoL). The psychological satisfaction in either group was studied by body image scale. Results: In the postoperative period, complication rate of 35% was noted in the study group as compared to 10% in the control group. In the study group, 95% of the patients were satisfied with the body image. Among these, 20% of patients were highly satisfied, 75% were moderately satisfied. On the other hand, 80% of the patients undergoing MRM alone were not satisfied at all. Conclusion: Immediate breast reconstruction following mastectomy is a logically better option to preserve the femininity, gives a higher level of patient satisfaction and significantly improves the quality of...

Parvinder Singh, Sanjeev Parshad, Mini Bedi

Dr SanjeevParshad, Professor, Department of Surgery, Postgraduate Institute of Medical Sciences, Rohtak (INDIA)

DOI:

1-6

2324

697

0

2.

PARTIAL NEPHRECTOMY FOR THE MANAGEMENT OF EARLY STAGE RENAL CANCER- IS IT TRENDING !

Partial nephrectomy is performed more commonly for small, low-stage renal tumors. The main advantage of partial nephrectomy over radical nephrectomy is the avoidance of renal insufficiency. The major disadvantages are the possibility of local recurrence and perioperative complications. In this article, we discuss the technical aspects of the nephron-sparing surgery and review the literature pertaining to it, in order to put the management of renal cancer into a modern...

Harbans Bansal, Ashwin Anand Kallianpur

Department of Urology, Indus Super-specialty Hospital, Mohali (INDIA)

DOI:

10-14

2245

697

0

2.

BREAST NODULAR HIDRADENOMA, A DIFFERENTIAL DIAGNOSIS OF BREAST CANCER

Abstract Nodular hidradenoma or clear cell hidradenoma is a rare skin adnexal tumor arising from eccrine sweat glands. Skin adnexal tumors situated in breast parenchyma are very rare and is one of differential diagnosis of breast masses. We report a case of 60 years old female with a left breast lump and bloody nipple discharge being suspected as a malignant breast mass. A final diagnosis of nodular hidradenoma breast was made after excision biopsy and immunohistochemistry study. A patient is a diagnosed case of carcinoma endometrium and underwent panhysterectomy in 2007. Postoperative histopathology revealed well-differentiated endometrial adenocarcinoma without invasion of the myometrium. She received postoperative radiation therapy and intravaginal brachytherapy in 2008 and is on regular follow-up since...

Mitanshu Sharma, Surendra Kumar Saini, Jitesh Sarvaiya, Pritesh Patel, Monika Vaghela

Surendra Kumar Saini, Assistant Professor, Department of Radiation Oncology, M P Shah Medical College & Associated G G Govt. Hospital, Jamnagar, Gujarat (INDIA)

DOI:

08-10

2163

791

0

2.

MIXED GERM CELL TUMOR OF OVARY AND MAYER ROKITANSKY KUSTNER HAUSER SYNDROME: AN UNUSUAL COMBINATION!

Germ cell tumor of ovary in young female is most common ovarian neoplasm but represent less than three percent of all ovarian malignancies in females. Mixed germ cell tumor is a variant of germ cell tumors and its presentation with Mayer Rokitansky Kustner Hauser Syndrome, which represents the most common type of utero-vaginal agenesis, is very unusual. However, for patients with primary amenorrhea, Mayer Rokitansky Kustner Hauser syndrome is the second common cause. We describe an interesting, uncommon and unexpected case in a young Indian female patient with primary amenorrhea due to this syndrome coexisting with mixed germ cell...

Rajiv Gandhi K, Surendra Kumar Saini, Jitesh Sarvaiya, Mitanshu Sharma, Dhara Kacha

Department of Radiotherapy & Oncology, M P Shah Medical College & Associated G G Govt. Hospital, Jamnagar, Gujarat (INDIA)

DOI:

11-13

2160

760

0

1.

CONCOMITANT CHEMORADIATION IN LOCALLY ADVANCED CARCINOMA CERVIX: COMPARING DOUBLET VERSUS SINGLE AGENT CHEMOTHERAPY.

Abstract Purpose: To compare the efficacy and toxicity of two definitive concomitant chemoradiotherapy schedules (doublet combination and single agent) along with radical external beam radiotherapy (EBRT) in the management of locally advanced carcinoma of the uterine cervix (LACCx). Material and method: Previously untreated, 60 patients of LACCx (FIGO stage IIB-IIIB) were taken for definitive treatment by concurrent chemo-radiation. These patients were randomly assigned either; Study group I, the Doublet chemotherapy(Gemcitabine + Cisplatin) administration and Control group II, the Single-agent chemotherapy(Cisplatin) administration group. EBRT was given as 50Gy/ 25Fr/ 5 weeks. Chemoradiation was followed by weekly HDR Intra-cavitory brachytherapy (ICBT), 3 sessions of 700cGy each. Observations were made at the end of treatment and 6 months of follow up. Response to treatment and toxicity were investigated. Results: At the end of treatment, disease response in study and control respectively at the end of treatment was as follows: Stage IIB (CR- 52.63% versus 38.09%), Stage IIIA (CR- 100% versus 100%) and Stage IIIB (CR- 55.56% versus 25.0%). Overall disease response for the group I and II, at the end of sixth months follow up was as follows: CR- 93.33% versus 83.33%, PR- 3.33% versus 13.33%, and recurrence- 3.33% versus 3.33% respectively. Most severe acute hematological toxicity observed was Grade 2 in 40.0% versus 16.67% patients, respectively. Similar was the trend of acute skin & mucosal reactions and acute gastrointestinal toxicity. Though a higher number of patients in the study group experienced more acute toxicities, these were acceptable and manageable. Skin and mucosal reactions at 6 months follow up were not significantly higher in the doublet group compared to the single agent group. Conclusion: Administration of doublet combination chemotherapy; is better compared to single-agent chemotherapy administration in terms of disease control (though not statistically significant)with manageable toxicity profile; given concurrent with EBRT, for management of locally advanced carcinoma cervix. A larger study may establish the very role of the new regimen, especially in a resource-limited setup where patients present with advanced/ bulky...

Vikas Gupta, Ashok K. Chauhan, Paramjeet Kaur, Yashpal Verma, Anil Khurana, Om Parkash

Dr. Yashpal Verma, Additional Senior Medical Officer, Department of Radiation Oncology, PGIMS Rohtak (India).

DOI:

01-07

2133

666

0

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