A RETROSPECTIVE ANALYSIS OF PALLIATIVE SURGICAL PROCEDURES FOR ADVANCED MALIGNANCIES IN A PRIVATE TERTIARY CANCER CARE CENTER.
Palliative surgery is an important, yet understudied aspect of palliative care. The present article emphasizes the diversity of palliative surgical procedures performed at a private tertiary cancer care center in India and the need of the multidisciplinary approach towards it. Though the overall morbidity and mortality is high, a significant number of cancer patients are alleviated from their symptoms and have a better quality of life, even in those with an anticipated short...
ROLE OF NATURALLY OCCURRING AGENTS IN TREATMENT OF RADIO-CHEMOTHERAPY INDUCED ORAL MUCOSITIS: A REVIEW
Mucositis is one of the most common side effects of the therapy for the management of cancer; be it radiotherapy, chemotherapy or combination of both. Oral mucositis is of very common occurrence in the patients who are treated for the squamous cell carcinoma of the head and neck region. The therapy targeted towards the oro-pharangeal region most often leads to this side effect. Not only the treatment regimen gets altered sometimes, but the quality of life of the patients also is compromised because of difficulty in normal intake of food. A wide range of mouthwashes, emollients and mucosal barriers have been tried to curb up the sequel of oral mucositis and every product has its limitations; be it the cost or side effects. Naturally occurring products have been available around us since the advent of mankind and various products have been used traditionally for their medicinal properties. This paper attempts to review an array of naturally occurring products which can be utilized for the treatment of radio-chemotherapy induced oral...
Background & Objective Lung Cancer is a major health problem worldwide with high fatality rate. Smoking is a known to be the most important risk factor, though all smokers do not develop lung cancer. This is because individuals differ in metabolism of pro-carcinogens present in cigarette smoke by cytochrome P450 (CYP 450) enzymes. Variable forms of CYP450 enzymes are produced due to presence of multiple alleles or polymorphs of CYP 450 gene. CYP 1A1 polymorphisms were the first CYP genes to be associated with lung cancer. Several single nucleotide polymorphisms (SNPs) have been identified in CYP1A1 gene, some of which are suspected to be linked with lung cancer. This study has been done to find association of CYP1A1 genes- m1, m2, and m4 polymorphism with lung cancer in heavy smokers. Methods & Results This is an observational analytical study on heavy smoker eighty males, of which forty were with lung cancer (Group I) and remaining forty were with non-lung cancer (Group II). CYP1A1 gene m1, m2 and m4 polymorphism was detected by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) techniques. Steps involved in these techniques are DNA isolation, polymerase chain reaction, DNA electrophoresis and restriction fragment length polymorphism. CYP1A1 m1 Gene polymorphism was found in 3 out of 22 (13.6%) cases of squamous cell lung cancer and only 1 case (4.5%) had both the m1 and m2 gene polymorphisms. None of these polymorphisms was seen in non-lung cancer smokers and in patients with non-squamous cell lung cancer. Interpretation & Conclusion CYP1A1 gene related m1 and m2 polymorphisms may have some contributory role for lung squamous cell carcinoma development and m4 polymorphism has no role in development of lung cancer in Indian population of eastern part of Gujarat. All lung carcinoma cases may not have gene polymorphism of CYP1A1...
Depression is a major psychiatric disorder producing non-pathological sadness and stress. Depression has a major negative impact on patients and their family member’s also. Overlapping of depressive symptoms with physical symptoms makes the diagnosis even more challenging. In biological mechanism, damage-associated molecular patterns (DAMPs) on damaged tissue bind to pattern recognition receptors (PRRs) on leukocytes, causing expression of transcription factor nuclear factor-κ-β (NFκβ) and production of numerous pro-inflammatory cytokines, including interleukin-1 (IL-1), interferon-α (INF-α), IL-6 and tumor necrosis factor (TNF). Some studies have reported delayed stress, addressing the need of mental health counseling throughout a continuum of care. Psychotherapy, in combination with antidepressant medications, and communication skills can act as a central component of patient care on the basic principle of physical, psychological, social and spiritual palliative...